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Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase (SERCA)

The anti-apoptotic effect of Bcl-2 is well established, but the detailed mechanisms are unknown. In the present study, we show in vitro a direct interaction of Bcl-2 with the rat skeletal muscle SERCA (sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase), leading to destabilization and inactivation of...

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Main Authors: Dremina, Elena S., Sharov, Victor S., Kumar, Keshava, Zaidi, Asma, Michaelis, Elias K., Schöneich, Christian
格式: Artigo
語言:Inglês
出版: Portland Press Ltd. 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134078/
https://ncbi.nlm.nih.gov/pubmed/15245329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040187
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