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Heat shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca(2+) mediated apoptosis

We had demonstrated that Bcl-2 and Bcl-2Δ21, a C-terminal truncated Bcl-2 sequence, inactivate SERCA1 in isolated sarcoplasmic reticulum (SR), accompanied by a translocation from caveolae-related domains of the SR. Here, we present evidence for the interaction of Bcl-2 with SERCA2b in C2C12 myoblast...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dremina, Elena S., Sharov, Victor S., Schöneich, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736812/
https://ncbi.nlm.nih.gov/pubmed/22360692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111114
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