Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases

PPM (polyprenol monophosphomannose) has been shown to act as a glycosyl donor in the biosynthesis of the Man (mannose)-rich mycobacterial lipoglycans LM (lipomannan) and LAM (lipoarabinomannan). The Mycobacterium tuberculosis PPM synthase (Mt-Ppm1) catalyses the transfer of Man from GDP-Man to polyp...

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Main Authors: Guy, Mark R., Illarionov, Petr A., Gurcha, Sudagar S., Dover, Lynn G., Gibson, Kevin J. C., Smith, Paul W., Minnikin, David E., Besra, Gurdyal S.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2004
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133966/
https://ncbi.nlm.nih.gov/pubmed/15202931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040911
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