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The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2
The transcriptional co-activator CBP [CREB (cAMP-response-element-binding protein)-binding protein] and its paralogue p300 play a key role in the regulation of both activity and stability of the tumour suppressor p53. Degradation of p53 is mediated by the ubiquitin ligase MDM2 (mouse double minute p...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1133877/ https://ncbi.nlm.nih.gov/pubmed/15154850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040564 |
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