Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain

Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein thiol groups is an emerging theme in signal-transduction research. We have found that MEKK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase...

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Bibliographic Details
Main Authors: Cross, Janet V., Templeton, Dennis J.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133876/
https://ncbi.nlm.nih.gov/pubmed/15139849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040591
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