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Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain
Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein thiol groups is an emerging theme in signal-transduction research. We have found that MEKK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Portland Press Ltd.
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1133876/ https://ncbi.nlm.nih.gov/pubmed/15139849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040591 |
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