Arginine(482) to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding

ABCG2 [also known as BCRP (breast cancer resistance protein) or MXR] is an ABC (ATP-binding cassette) protein shown to confer multidrug resistance. ABCG2 was initially identified in resistant breast carcinoma cells (MCF-7/AdrVp1000) selected with doxorubicin and verapamil. Later studies demonstrated...

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Bibliographic Details
Main Authors: Alqawi, Omar, Bates, Susan, Georges, Elias
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133829/
https://ncbi.nlm.nih.gov/pubmed/15139851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040355
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