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Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insulin resistance that may develop, in part, as a consequence of a direct inhibitory effect on early insulin signalling events. Here we report work investigating the mechanism by which palmitate (a satura...

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Bibliografski detalji
Glavni autori: Powell, Darren J., Turban, Sophie, Gray, Alexander, Hajduch, Eric, Hundal, Harinder S.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133819/
https://ncbi.nlm.nih.gov/pubmed/15193147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040139
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