Thimerosal stimulates Ca(2+) flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca(2+)-dependent intramolecular interaction

Thiol-reactive agents such as thimerosal have been shown to modulate the Ca(2+)-flux properties of IP(3) (inositol 1,4,5-trisphosphate) receptor (IP(3)R) via an as yet unidentified mechanism [Parys, Missiaen, De Smedt, Droogmans and Casteels (1993) Pflügers Arch. 424, 516–522; Kaplin, Ferris, Voglma...

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Main Authors: Bultynck, Geert, Szlufcik, Karolina, Kasri, Nael Nadif, Assefa, Zerihun, Callewaert, Geert, Missiaen, Ludwig, Parys, Jan B., De Smedt, Humbert
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2004
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133765/
https://ncbi.nlm.nih.gov/pubmed/15015936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040072
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