The G115S mutation associated with maturity-onset diabetes of the young impairs hepatocyte nuclear factor 4α activities and introduces a PKA phosphorylation site in its DNA-binding domain

HNF4α (hepatocyte nuclear factor 4α) belongs to a complex transcription factor network that is crucial for the function of hepatocytes and pancreatic β-cells. In these cells, it activates the expression of a very large number of genes, including genes involved in the transport and metabolism of gluc...

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Autores principales: Oxombre, Bénédicte, Kouach, Mostafa, Moerman, Ericka, Formstecher, Pierre, Laine, Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2004
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133751/
https://ncbi.nlm.nih.gov/pubmed/15233628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040473
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