Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments.

The epitopes of four monoclonal antibodies against coagulation Factor VIII were mapped with the use of recombinant DNA techniques. Full-length Factor VIII cDNA and parts thereof were inserted into the vector pSP64, permitting transcription in vitro with the use of a promoter specific for SP6 RNA pol...

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Hauptverfasser: Leyte, A, Mertens, K, Distel, B, Evers, R F, De Keyzer-Nellen, M J, Groenen-Van Dooren, M M, De Bruin, J, Pannekoek, H, Van Mourik, J A, Verbeet, M P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133407/
https://ncbi.nlm.nih.gov/pubmed/2481438
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