Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations

BACKGROUND: The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold higher frequency of spontaneous mutations co...

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Hlavní autoři: Duffy, Karen E, Quail, Matthew R, Nguyen, Tammy T, Wittrock, Robert J, Bartus, Joan O, Halsey, Wendy M, Leary, Jeffry J, Bacon, Teresa H, Sarisky, Robert T
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2002
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC113270/
https://ncbi.nlm.nih.gov/pubmed/12019036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-2-7
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