Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells.

Thapsigargin, a tumour-promoting sesquiterpene lactone, selectively inhibits the Ca(2+)-ATPase responsible for Ca2+ accumulation by the endoplasmic reticulum (ER). Mobilization of ER-sequestered Ca2+ to the cytosol and to the extracellular fluid subsequently ensues, with concomitant alteration of ce...

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Detalhes bibliográficos
Main Authors: Wong, W L, Brostrom, M A, Kuznetsov, G, Gmitter-Yellen, D, Brostrom, C O
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132132/
https://ncbi.nlm.nih.gov/pubmed/8424774
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