p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

Adult mammalian cardiomyocytes are considered terminally differentiated and incapable of proliferation. Consequently, acutely injured mammalian hearts do not regenerate, they scar. Here, we show that adult mammalian cardiomyocytes can divide. One important mechanism used by mammalian cardiomyocytes...

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Bibliographic Details
Main Authors: Engel, Felix B., Schebesta, Michael, Duong, Mychelle T., Lu, Gang, Ren, Shuxun, Madwed, Jeffery B., Jiang, Huiping, Wang, Yibin, Keating, Mark T.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132004/
https://ncbi.nlm.nih.gov/pubmed/15870258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1306705
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