Disruption of Virion Host Shutoff Activity Improves the Immunogenicity and Protective Capacity of a Replication-Incompetent Herpes Simplex Virus Type 1 Vaccine Strain

The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but i...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Geiss, Brian J., Smith, Tracy J., Leib, David A., Morrison, Lynda A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Vaccines and Antiviral Agents
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113198/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11070010/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.23.11137-11144.2000
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