Importance of the His-298 residue in the catalytic mechanism of the Streptomyces R61 extracellular DD-peptidase.

Among the active-site-serine penicillin-recognizing proteins, the Streptomyces R61 extracellular DD-peptidase is the only one to have a His-Thr-Gly sequence [instead of Lys-Thr(Ser)-Gly] in 'box' VII. The His residue was replaced by Gln or Lys. Both mutations induced a marked decrease in t...

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Bibliographic Details
Main Authors: Hadonou, A M, Jamin, M, Adam, M, Joris, B, Dusart, J, Ghuysen, J M, Frère, J M
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130807/
https://ncbi.nlm.nih.gov/pubmed/1546964
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