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Concatamerization of Adeno-Associated Virus Circular Genomes Occurs through Intermolecular Recombination

Long-term recombinant AAV (rAAV) transgene expression in muscle has been associated with the molecular conversion of single-stranded rAAV genomes to high-molecular-weight head-to-tail circular concatamers. However, the mechanisms by which these large multimeric concatamers form remain to be defined....

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Udgivet i:J Virol
Principais autores: Yang, Jusan, Zhou, Weihong, Zhang, Yulong, Zidon, Terese, Ritchie, Terry, Engelhardt, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112981/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10516055/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.11.9468-9477.1999
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