Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAA...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Duan, Dongsheng, Sharma, Prerna, Yang, Jusan, Yue, Yongping, Dudus, Lorita, Zhang, Yulong, Fisher, Krishna J., Engelhardt, John F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1998
Ämnen:
Gene Therapy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC110267/
https://ncbi.nlm.nih.gov/pubmed/9765395
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk