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Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAA...

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Publicado no:J Virol
Principais autores: Duan, Dongsheng, Sharma, Prerna, Yang, Jusan, Yue, Yongping, Dudus, Lorita, Zhang, Yulong, Fisher, Krishna J., Engelhardt, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1998
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110267/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9765395/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.11.8568-8577.1998
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