Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAA...

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Bibliographische Detailangaben
Hauptverfasser: Duan, Dongsheng, Sharma, Prerna, Yang, Jusan, Yue, Yongping, Dudus, Lorita, Zhang, Yulong, Fisher, Krishna J., Engelhardt, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC110267/
https://ncbi.nlm.nih.gov/pubmed/9765395
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