Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAA...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Duan, Dongsheng, Sharma, Prerna, Yang, Jusan, Yue, Yongping, Dudus, Lorita, Zhang, Yulong, Fisher, Krishna J., Engelhardt, John F.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Materias:	Gene Therapy
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110267/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9765395/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.11.8568-8577.1998
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