Concatamerization of Adeno-Associated Virus Circular Genomes Occurs through Intermolecular Recombination

Long-term recombinant AAV (rAAV) transgene expression in muscle has been associated with the molecular conversion of single-stranded rAAV genomes to high-molecular-weight head-to-tail circular concatamers. However, the mechanisms by which these large multimeric concatamers form remain to be defined....

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Autores principales: Yang, Jusan, Zhou, Weihong, Zhang, Yulong, Zidon, Terese, Ritchie, Terry, Engelhardt, John F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1999
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC112981/
https://ncbi.nlm.nih.gov/pubmed/10516055
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