Altered Virulence of Vaccine Strains of Measles Virus after Prolonged Replication in Human Tissue

To understand the molecular determinants of measles virus (MV) virulence, we have used the SCID-hu thymus/liver xenograft model (SCID-hu thy/liv) in which in vivo MV virulence phenotypes are faithfully duplicated. Stromal epithelial and monocytic cells are infected by MV in thymus implants, and viru...

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Main Authors: Valsamakis, Alexandra, Auwaerter, Paul G., Rima, Bert K., Kaneshima, Hideto, Griffin, Diane E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC112900/
https://ncbi.nlm.nih.gov/pubmed/10482633
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