Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections

The human MxA protein is part of the antiviral state induced by alpha/beta interferon (IFN-α/β). MxA inhibits the multiplication of several RNA viruses in cell culture. However, its antiviral potential in vivo has not yet been fully explored. We have generated MxA-transgenic mice that lack a functio...

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Pubblicato in:	J Virol
Autori principali:	Hefti, Hans Peter, Frese, Michael, Landis, Heinrich, Di Paolo, Claudio, Aguzzi, Adriano, Haller, Otto, Pavlovic, Jovan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112784/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10400797/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.8.6984-6991.1999
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