Escape of Human Cytomegalovirus from HLA-DR-Restricted CD4(+) T-Cell Response Is Mediated by Repression of Gamma Interferon-Induced Class II Transactivator Expression

Human cytomegalovirus (HCMV), a betaherpesvirus, is a pathogen which escapes immune recognition through various mechanisms. In this paper, we show that HCMV down regulates gamma interferon (IFN-γ)-induced HLA-DR expression in U373 MG astrocytoma cells due to a defect downstream of STAT1 phosphorylat...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Le Roy, Emmanuelle, Mühlethaler-Mottet, Annick, Davrinche, Christian, Mach, Bernard, Davignon, Jean-Luc
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112742/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10400755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.8.6582-6589.1999
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