Isolation and Molecular Characterization of a Poliovirus Type 1 Mutant That Replicates in the Spinal Cords of Mice

The Mahoney strain of poliovirus type 1 (OM) is generally unable to cause paralysis in mice. We isolated a mouse-adapted mutant, PV1/OM-SA (SA), from the spinal cord of a mouse that had been intracerebrally inoculated with OM. SA showed mouse neurovirulence only with intraspinal inoculation, and the...

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Vydáno v:	J Virol
Hlavní autoři:	Jia, Qingmei, Ohka, Seii, Iwasaki, Kuniko, Tohyama, Koujiro, Nomoto, Akio
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364356/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.6041-6047.1999
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