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Isolation and Molecular Characterization of a Poliovirus Type 1 Mutant That Replicates in the Spinal Cords of Mice

The Mahoney strain of poliovirus type 1 (OM) is generally unable to cause paralysis in mice. We isolated a mouse-adapted mutant, PV1/OM-SA (SA), from the spinal cord of a mouse that had been intracerebrally inoculated with OM. SA showed mouse neurovirulence only with intraspinal inoculation, and the...

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Detalhes bibliográficos
Main Authors: Jia, Qingmei, Ohka, Seii, Iwasaki, Kuniko, Tohyama, Koujiro, Nomoto, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112665/
https://ncbi.nlm.nih.gov/pubmed/10364356
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