Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells

Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virus (MSCV) vector completely silences β-globin reporter genes regulated by locus control region (LCR) elements 5′HS...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Osborne, Cameron S., Pasceri, Peter, Singal, Rakesh, Sukonnik, Tanya, Ginder, Gordon D., Ellis, James
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Gene Therapy
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5490-5496.1999
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