Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells

Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virus (MSCV) vector completely silences β-globin reporter genes regulated by locus control region (LCR) elements 5′HS...

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Detaylı Bibliyografya
Yayımlandı:	J Virol
Asıl Yazarlar:	Osborne, Cameron S., Pasceri, Peter, Singal, Rakesh, Sukonnik, Tanya, Ginder, Gordon D., Ellis, James
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 1999
Konular:	Gene Therapy
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5490-5496.1999
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Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells

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