Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells

Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virus (MSCV) vector completely silences β-globin reporter genes regulated by locus control region (LCR) elements 5′HS...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Osborne, Cameron S., Pasceri, Peter, Singal, Rakesh, Sukonnik, Tanya, Ginder, Gordon D., Ellis, James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 1999
Gaiak:
Gene Therapy
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC112606/
https://ncbi.nlm.nih.gov/pubmed/10364297
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