Amelioration of Retroviral Vector Silencing in Locus Control Region β-Globin-Transgenic Mice and Transduced F9 Embryonic Cells

Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virus (MSCV) vector completely silences β-globin reporter genes regulated by locus control region (LCR) elements 5′HS...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Osborne, Cameron S., Pasceri, Peter, Singal, Rakesh, Sukonnik, Tanya, Ginder, Gordon D., Ellis, James
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Gene Therapy
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5490-5496.1999
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