Combinatorial Screening and Intracellular Antiviral Activity of Hairpin Ribozymes Directed against Hepatitis B Virus

A combinatorial screening method has been used to identify hairpin ribozymes that inhibit hepatitis B virus (HBV) replication in transfected human hepatocellular carcinoma (HCC) cells. A hairpin ribozyme library (5 × 10(5) variants) containing a randomized substrate-binding domain was used to identi...

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Vydáno v:	J Virol
Hlavní autoři:	zu Putlitz, Jasper, Yu, Qiao, Burke, John M., Wands, Jack R.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1999
Témata:	Replication
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112594/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364285/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5381-5387.1999
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