Affinity-Tagged Miniprion Derivatives Spontaneously Adopt Protease-Resistant Conformations

An abridged PrP molecule of 106 amino acids designated PrP106 can form infectious miniprions in transgenic (Tg) mice (29). Addition of six-histidine (His(6)) affinity tags to selective sites within PrP106 resulted unexpectedly in new PrP proteins that spontaneously adopted protease-resistant conform...

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Publié dans:	J Virol
Auteurs principaux:	Supattapone, Surachai, Nguyen, Hoang-Oanh B., Muramoto, Tamaki, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B., Scott, Michael
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Structure and Assembly
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11090193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.24.11928-11934.2000
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