Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells

Alphavirus replicon vectors are well suited for applications where transient, high-level expression of a heterologous gene is required. Replicon vector expression in cells leads to inhibition of host macromolecular synthesis, culminating in eventual cell death by an apoptotic mechanism. For many app...

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Bibliographic Details
Main Authors: Perri, Silvia, Driver, David A., Gardner, Jason P., Sherrill, Scott, Belli, Barbara A., Dubensky, Thomas W., Polo, John M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112418/
https://ncbi.nlm.nih.gov/pubmed/11000258
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