Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this goal, we derived variants of the prototype alphavirus, Sindbis virus (SIN), with differential abilit...

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Detalhes bibliográficos
Main Authors: Gardner, Jason P., Frolov, Ilya, Perri, Silvia, Ji, Yaying, MacKichan, Mary Lee, zur Megede, Jan, Chen, Minchao, Belli, Barbara A., Driver, David A., Sherrill, Scott, Greer, Catherine E., Otten, Gillis R., Barnett, Susan W., Liu, Margaret A., Dubensky, Thomas W., Polo, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112468/
https://ncbi.nlm.nih.gov/pubmed/11090185
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