Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells

Alphavirus replicon vectors are well suited for applications where transient, high-level expression of a heterologous gene is required. Replicon vector expression in cells leads to inhibition of host macromolecular synthesis, culminating in eventual cell death by an apoptotic mechanism. For many app...

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Pubblicato in:	J Virol
Autori principali:	Perri, Silvia, Driver, David A., Gardner, Jason P., Sherrill, Scott, Belli, Barbara A., Dubensky, Thomas W., Polo, John M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112418/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11000258/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.20.9802-9807.2000
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