Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus

In contrast to wild-type mouse mammary tumor virus (MMTV), the MMTV mutants with specific deletions in the U3 region of their long terminal repeats cause T-cell lymphomas. In 30% of T-cell lymphomas arising in BALB/c mice infected with MLA-MMTV, a leukemogenic MMTV mutant, we have found that MMTV pr...

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Bibliographic Details
Main Authors: Yanagawa, Shin-ichi, Lee, Jong-Seo, Kakimi, Kazuhiro, Matsuda, Yukihiro, Honjo, Tasuku, Ishimoto, Akinori
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112415/
https://ncbi.nlm.nih.gov/pubmed/11000255
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