Activated Notch1 Inhibits p53-Induced Apoptosis and Sustains Transformation by Human Papillomavirus Type 16 E6 and E7 Oncogenes through a PI3K-PKB/Akt-Dependent Pathway

Activated Notch1 (AcN1) alleles cooperate with oncogenes from DNA tumor viruses in transformation of epithelial cells. AcN1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin D1 or the generation of resistance to apoptosis on matrix withdraw...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Nair, Pradip, Somasundaram, Kumaravel, Krishna, Sudhir
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Transformation and Oncogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156194/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12768030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.12.7106-7112.2003
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