Activated Notch1 Inhibits p53-Induced Apoptosis and Sustains Transformation by Human Papillomavirus Type 16 E6 and E7 Oncogenes through a PI3K-PKB/Akt-Dependent Pathway

Activated Notch1 (AcN1) alleles cooperate with oncogenes from DNA tumor viruses in transformation of epithelial cells. AcN1 signaling has pleiotropic effects, and suggested oncogenic roles include driving proliferation through cyclin D1 or the generation of resistance to apoptosis on matrix withdraw...

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Bibliografski detalji

Izdano u:	J Virol
Glavni autori:	Nair, Pradip, Somasundaram, Kumaravel, Krishna, Sudhir
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2003
Teme:	Transformation and Oncogenesis
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156194/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12768030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.12.7106-7112.2003
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