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Diminished Primary and Secondary Influenza Virus-Specific CD8(+) T-Cell Responses in CD4-Depleted Ig(−/−) Mice

Optimal expansion of influenza virus nucleoprotein (D(b)NP(366))-specific CD8(+) T cells following respiratory challenge of naive Ig(−/−) μMT mice was found to require CD4(+) T-cell help, and this effect was also observed in primed animals. Absence of the CD4(+) population was consistently correlate...

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Autors principals: Riberdy, Janice M., Christensen, Jan P., Branum, Kristen, Doherty, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC112411/
https://ncbi.nlm.nih.gov/pubmed/11000251
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