Diminished Primary and Secondary Influenza Virus-Specific CD8(+) T-Cell Responses in CD4-Depleted Ig(−/−) Mice

Optimal expansion of influenza virus nucleoprotein (D(b)NP(366))-specific CD8(+) T cells following respiratory challenge of naive Ig(−/−) μMT mice was found to require CD4(+) T-cell help, and this effect was also observed in primed animals. Absence of the CD4(+) population was consistently correlate...

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Pubblicato in:	J Virol
Autori principali:	Riberdy, Janice M., Christensen, Jan P., Branum, Kristen, Doherty, Peter C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11000251/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.20.9762-9765.2000
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