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Unusual Distribution of Mutations Associated with Serial Bottleneck Passages of Human Immunodeficiency Virus Type 1

Repeated bottleneck passages result in fitness losses of RNA viruses. In the case of human immunodeficiency virus type 1 (HIV-1), decreases in fitness after a limited number of plaque-to-plaque transfers in MT-4 cells were very drastic. Here we report an analysis of entire genomic nucleotide sequenc...

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Bibliografiska uppgifter
Huvudupphovsmän: Yuste, Eloisa, López-Galíndez, Cecilio, Domingo, Esteban
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC112385/
https://ncbi.nlm.nih.gov/pubmed/11000225
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