Loss of Heterozygosity at the Ink4a/Arf Locus Facilitates Abelson Virus Transformation of Pre-B Cells

In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV)...

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Pubblicato in:	J Virol
Autori principali:	Mostecki, Justin, Halgren, Anne, Radfar, Arash, Sachs, Zohar, Ravitz, James, Thome, Kelly C., Rosenberg, Naomi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Transformation and Oncogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11000217/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.20.9479-9487.2000
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