Loss of Heterozygosity at the Ink4a/Arf Locus Facilitates Abelson Virus Transformation of Pre-B Cells

In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV)...

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Библиографические подробности
Главные авторы: Mostecki, Justin, Halgren, Anne, Radfar, Arash, Sachs, Zohar, Ravitz, James, Thome, Kelly C., Rosenberg, Naomi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
Предметы:
Transformation and Oncogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC112377/
https://ncbi.nlm.nih.gov/pubmed/11000217
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