Loss of Heterozygosity at the Ink4a/Arf Locus Facilitates Abelson Virus Transformation of Pre-B Cells

In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV)...

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Autors principals: Mostecki, Justin, Halgren, Anne, Radfar, Arash, Sachs, Zohar, Ravitz, James, Thome, Kelly C., Rosenberg, Naomi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Transformation and Oncogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC112377/
https://ncbi.nlm.nih.gov/pubmed/11000217
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