Recruitment of Single-Stranded Recombinant Adeno-Associated Virus Vector Genomes and Intermolecular Recombination Are Responsible for Stable Transduction of Liver In Vivo

Recombinant adeno-associated virus (rAAV) vectors stably transduce hepatocytes in experimental animals. Following portal-vein administration of rAAV vectors in vivo, single-stranded (ss) rAAV genomes become double stranded (ds), circularized, and/or concatemerized concomitant with a slow rise and, e...

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Pubblicato in:	J Virol
Autori principali:	Nakai, Hiroyuki, Storm, Theresa A., Kay, Mark A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Gene Therapy
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11000214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.20.9451-9463.2000
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