Structural Determinants of Murine Leukemia Virus Reverse Transcriptase That Affect the Frequency of Template Switching

Retroviral reverse transcriptases (RTs) frequently switch templates within the same RNA or between copackaged viral RNAs to generate mutations and recombination. To identify structural elements of murine leukemia virus RT important for template switching, we developed an in vivo assay in which RT te...

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Bibliographic Details
Main Authors: Svarovskaia, Evguenia S., Delviks, Krista A., Hwang, Carey K., Pathak, Vinay K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112237/
https://ncbi.nlm.nih.gov/pubmed/10888659
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