Evaluation of Hepatitis C Virus Glycoprotein E2 for Vaccine Design: an Endoplasmic Reticulum-Retained Recombinant Protein Is Superior to Secreted Recombinant Protein and DNA-Based Vaccine Candidates

Hepatitis C virus (HCV) is the leading causative agent of blood-borne chronic hepatitis and is the target of intensive vaccine research. The virus genome encodes a number of structural and nonstructural antigens which could be used in a subunit vaccine. The HCV envelope glycoprotein E2 has recently...

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Autori principali: Heile, Jens M., Fong, Yiu-Lian, Rosa, Domenico, Berger, Kim, Saletti, Giulietta, Campagnoli, Susanna, Bensi, Giuliano, Capo, Sabrina, Coates, Steve, Crawford, Kevin, Dong, Christine, Wininger, Mark, Baker, Gary, Cousens, Larry, Chien, David, Ng, Philip, Archangel, Phillip, Grandi, Guido, Houghton, Michael, Abrignani, Sergio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC112206/
https://ncbi.nlm.nih.gov/pubmed/10888628
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