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Gamma Interferon Impedes the Establishment of Herpes Simplex Virus Type 1 Latent Infection but Has No Impact on Its Maintenance or Reactivation in Mice

Murine models of gamma interferon (IFN-γ) deficiency demonstrate the role of this cytokine in attenuating acute herpes simplex virus (HSV) disease; however, the effect of IFN-γ on the establishment and maintenance of neuronal latency and viral reactivation is not known. Using the IFN-γ knockout (GKO...

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Detalhes bibliográficos
Main Authors: Lekstrom-Himes, Julie A., LeBlanc, Rona A., Pesnicak, Lesley, Godleski, Matthew, Straus, Stephen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112181/
https://ncbi.nlm.nih.gov/pubmed/10864685
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