Wild-Type and YMDD Mutant Murine Leukemia Virus Reverse Transcriptases Are Resistant to 2′,3′-Dideoxy-3′-Thiacytidine

The antiretroviral nucleoside analog 2′,3′-dideoxy-3′-thiacytidine (3TC) is a potent inhibitor of wild-type human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). A methionine-to-valine or methionine-to-isoleucine substitution at residue 184 in the HIV-1 YMDD motif, which is located...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Halvas, Elias K., Svarovskaia, Evguenia S., Freed, Eric O., Pathak, Vinay K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6669-6674.2000
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