Wild-Type and YMDD Mutant Murine Leukemia Virus Reverse Transcriptases Are Resistant to 2′,3′-Dideoxy-3′-Thiacytidine
The antiretroviral nucleoside analog 2′,3′-dideoxy-3′-thiacytidine (3TC) is a potent inhibitor of wild-type human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). A methionine-to-valine or methionine-to-isoleucine substitution at residue 184 in the HIV-1 YMDD motif, which is located...
Kaydedildi:
| Yayımlandı: | J Virol |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology (ASM)
2000
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6669-6674.2000 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|