Selective Membrane Permeabilization by the Rotavirus VP5* Protein Is Abrogated by Mutations in an Internal Hydrophobic Domain

Rotavirus infectivity is dependent on the proteolytic cleavage of the VP4 spike protein into VP8* and VP5* proteins. Proteolytically activated virus, as well as expressed VP5*, permeabilizes membranes, suggesting that cleavage exposes a membrane-interactive domain of VP5* which effects rapid viral e...

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Bibliographic Details
Main Authors: Dowling, William, Denisova, Evgeniya, LaMonica, Rachel, Mackow, Erich R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112143/
https://ncbi.nlm.nih.gov/pubmed/10864647
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