Selective Membrane Permeabilization by the Rotavirus VP5* Protein Is Abrogated by Mutations in an Internal Hydrophobic Domain

Rotavirus infectivity is dependent on the proteolytic cleavage of the VP4 spike protein into VP8* and VP5* proteins. Proteolytically activated virus, as well as expressed VP5*, permeabilizes membranes, suggesting that cleavage exposes a membrane-interactive domain of VP5* which effects rapid viral e...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Dowling, William, Denisova, Evgeniya, LaMonica, Rachel, Mackow, Erich R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112143/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864647/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6368-6376.2000
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