Evolution of Lamivudine Resistance in Human Immunodeficiency Virus Type 1-Infected Individuals: the Relative Roles of Drift and Selection

Human immunodeficiency virus type 1 (HIV-1) rapidly develops resistance to lamivudine during monotherapy, typically resulting in the appearance at position 184 in reverse transcriptase (RT) of isoleucine instead of the wild-type methionine (M184I) early in therapy, which is later replaced by valine...

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Detalhes bibliográficos
Main Authors: Frost, Simon D. W., Nijhuis, Monique, Schuurman, Rob, Boucher, Charles A. B., Brown, Andrew J. Leigh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Recombination and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC112131/
https://ncbi.nlm.nih.gov/pubmed/10864635
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